Product Overview

What makes 110% Nutrition PreWorkout stand out among our competitors?

Description of our Comprehensive Non-Stim PreWorkout

Ingredient Breakdown

 L-Citrulline Malate

Citrulline Malate is a powerful amino acid that is commonly used in PreWorkout products to stimulate more efficient Nitric Oxide production. This ingredient is mainly used to deliver the maximum amount of blood and nutrients to your muscles to give you the most incredible muscle pumps in the gym. Citrulline is also shown to increase athletic performance and cardiovascular health when taken in sufficient doses. A full serving of 110% Nutrition Preworkout contains the clinical dose that is recommended for optimal performance.

     In clinical studies, Citrulline is shown to: 

• Improve training performance
  
• Reduce muscle fatigue 
  
• Improve blood circulation
  
• Boost immunity
  
• Promote muscle recovery
  
• Enhance your body's natural Nitric Oxide production leading to improved vasodilation

References:

Citrulline Malate Enhances Athletic Anaerobic Performance and Relieves Muscle Soreness

https://journals.lww.com/nsca-jscr/FullText/2010/05000/Citrulline_Malate_Enhances_Athletic_Anaerobic.9.aspx

Citrulline Malate promotes aerobic energy production in human exercising muscle

https://bjsm.bmj.com/content/36/4/282.abstract

Effects of supplemental citrulline malate ingestion during repeated bouts of lower-body exercise in advanced weightlifters:

https://www.ncbi.nlm.nih.gov/pubmed/25226311

Effects of Supplemental Citrulline-Malate Ingestion on Blood Lactate, Cardiovascular Dynamics, and Resistance Exercise Performance in Trained Males

https://www.tandfonline.com/doi/abs/10.3109/19390211.2015.1008615

L-citrulline-malate influence over branched chain amino acid utilization during exercise

https://www.ncbi.nlm.nih.gov/pubmed/20499249 

Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females

https://link.springer.com/article/10.1007/s00394-015-1124-6

 Betaine Anhydrous

Betaine Anhydrous is a component that occurs naturally in Glycine, a common amino acid typically found in foods such as shellfish, beets, spinach, and wheat. Betaine has been shown to be a key ingredient to boost strength and energy levels while increasing muscular endurance during high intensity exercise. Betaine also works to keep muscles hydrated when under stress to reduce inflammation and further minimize fatigue. This performance boosting ingredient will help to increase your power and force output to ensure you grow stronger and increase your stamina with each session.

References:

Effects of betaine on body composition, performance, and homocysteine thiolactone

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844502/

Ergogenic effects of betaine supplementation on strength and power performance

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915951/

The effects of chronic betaine supplementation on body composition and performance in collegiate females: a double-blind, randomized, placebo controlled trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069865/

 Nitrosigine®

Nitrosigine® is a patented complex of Bonded Arginine Silicate that is scientifically engineered to deliver benefits essential to peak sports performance. Nitrosigine® is a powerful and safe non-stimulant ingredient that has been clinically studied for safety and efficacy in 30 studies. The use of Nitrosigine® has been shown to promote nitric oxide (NO) production for improved blood flow, focus, and energy. The unique complex of arginine and silicon in Nitrosigine® unlocks powerful synergistic effects that offer enhanced benefits. Arginine contributes to boosting nitric oxide (NO) levels, which has been shown to be a key factor in generating greater blood flow and vasodilation in working muscles. Meanwhile, silicon contributes to blood flow by strengthening and improving the flexibility of arterial walls. Together, these ingredients offer powerful efficacious results compared to each ingredient alone. Nitrosigine® increases blood levels of arginine for up to six hours and elevates blood levels of silicon with a single dose. If safety is a concern, the company behind Nitrosigine® has conducted 140 studies (and counting) to support the safety and effectiveness of their ingredients.

Size Does Matter: In March of 2020, researchers at The University of Arkansas published an independent study that showed that a single dose of Nitrosigine® increases blood flow and vasodilation. In fact, it only took 1.5g of Nitrosigine® vs. 8g of Citrulline Malate to achieve the same result.

     The top benefits include...

     Power:

• Nitrosigine boosts key factors for increasing blood flow
  
• Nitrosigine significantly boosts nitric oxide (NO) levels
  

     Time Optimized Results:

• Nitrosigine provides improved cognitive flexibility within just 15 minutes
  
• After a single dose, Nitrosigine increases blood arginine levels in as quickly as 30 minutes and lasts up to 6 hours
  

     Strength:

• Nitrosigine begins to increase energy levels in a single dose vs. baseline and continues to show increases in energy over time
  

     Muscle Pump:

• Nitrosigine boosts muscle pump and shows significant increases in muscle volume
  

     Focus/Cognitive Function:

• Nitrosigine significantly increases cognitive function, mental acuity, and focus
  
• Nitrosigine prevented the decline in cognitive function caused by intense exercise in a research study
  

     Endurance/Recovery:

• Nitrosigine reduces markers of muscle damage from exercise
  
• Nitrosigine improves muscle recovery after exercise

References:

Randomized Prospective Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized Arginine Silicate in Healthy Physically Active Adults

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133120/

A Review of the Single-Dose Pharmacokinetics of Different Delivery Forms of Inositol-Stabilized Arginine Silicate (Nitrosigine®) in Healthy Males 

https://academic.oup.com/cdn/article/5/Supplement_2/335/6293365

The effects of inositol-stabilized arginine silicate (ASI; Nitrosigine) on cognitive function in females with different activity levels 

https://scholarworks.uark.edu/hhpruht/110/

Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041093/ 

Bonded arginine silicate: raising the bar  

 https://nutrition21.com/wp-content/uploads/2020/10/Nutraceutical-Business-Review-Nitrosigine®.pdf

A clinical evaluation to determine the safety, pharmacokinetics and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males. 

https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.28.1_supplement.lb418

(The above information was taken directly from the Nitrosigine® product information page developed by Nutrition21, LLC. - https://nutrition21.com/nitrosigine/) 

 Peak O2®

This patented ingredient (produced by Compound Solutions, Inc.) is an essential component to a PreWorkout product as it is highly respected for its clinically proven strength and endurance boosting properties. PeakO2® is an organic-certified combination of six adaptogenic mushrooms grown here in the U.S. This specific blend allows users to "adapt" to and overcome physical and mental stress by increasing their power and endurance. PeakO2® also helps improve oxygen utilization and work capacity while decreasing lactate buildup, helping athletes train longer and harder. Essentially, the benefits are proven to delay your body's time to exhaustion making it an ideal supplement if you need endurance in any capacity. You will be able to take advantage of all these performance benefits while experiencing the perfect combination of drinkability and efficacy, making it an extremely versatile ingredient.

In the first 7 days of a 21-day clinical study at the University of North Carolina, Chapel Hill, competitive athletes supplementing with 4g per day of PeakO2® improved their peak power output 17.6% over baseline. The placebo group decreased 11.8% compared to baseline.

In a study with 28 individuals, there was a significant improvement of nearly 4ml/kg/min for maximum oxygen consumption (VO2 max) in the group taking Peak O2. This is significant, physiologically speaking, as well. PeakO2® promotes oxygen consumption during exercise, which is foundational to all exercise from running or walking to CrossFit or bodybuilding.

The 28 UNC athletes underwent 6 minutes of high-intensity cycling and a three-minute bicycle sprint. The PeakO2® group improved time to exhaustion by 70 seconds, compared to a 5-second improvement in the placebo group. The results trended toward significance.

In a study with 40 individuals, PeakO2® had a significant improvement on blood lactate levels. Observed together with improved oxygen consumption, PeakO2® may support ATP production for optimizing exercise performance.  

     The top benefits include...

     General Wellness

• The natural carbohydrates in mushrooms are called polysaccharides. These are prebiotics which are beneficial for the gut. This means in addition to all of the other advantages, you can improve gut health, which we all know is important to overall human health.

     Optimal Oxygen Release 

• This unique blend also allows your body to access more oxygen, faster and longer. This is imperative as our muscles need oxygen… but when stressed, your muscles need even more oxygen.

     Sustained energy

     PeakO2® has been clinically shown to:

• Reduce lactate buildup, supporting ATP production
  
• Promote improved Oxygen consumption during exercise
  
• Promote increased time to fatigue
  

References:

Hirsch, et. al., Cordyceps militaris improves tolerance to high-intensity exercise after acute and chronic supplementation, 2016.

Dudgeon, et. Al., The effects of high and low-dose cordyceps militaris-containing mushroom blend supplementation after seven and twenty-eight days, 2018.

Chronic supplementation of a mushroom blend on oxygen kinetics, peak power, and time to exhaustion 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594151/

(The above information was taken directly from the PeakO2® product information page developed by Compound Solutions, Inc. - https://compoundsolutions.com/ingredients/peako2/ )

Choline L-Bitartrate 

Choline Bitartrate is derived from the B-Vitamin family and is not naturally produced within the body. Therefore, it is considered an essential nutrient that can only be utilized through proper supplementation. This ingredient is present in our Non-Stim PreWorkout because it has been shown to be one of the most well rounded, effective nootropics due to its many physical and psychological benefits. The main physical benefits include better cardiovascular health, reinforced cell-membranes, reduced risk of disease in breast tissue, and minimized fat build-up in the liver. Meanwhile, the list of psychological benefits include increased long/short term memory, enhanced focus and alertness, stabilized mood and minimized "foggy" or "hazy" feeling. This mood boosting ingredient will leave you in the perfect mental state to power through a hard workout!

References:

Choline, an essential nutrient for humans

https://pubmed.ncbi.nlm.nih.gov/2010061/

Choline: an important micronutrient for maximal endurance-exercise performance?

https://pubmed.ncbi.nlm.nih.gov/18458362/

Choline metabolism and risk of breast cancer in a population-based study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430758/

Choline: An Essential Nutrient for Public Health

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782876/

L-Tyrosine 

L-Tyrosine is an amino acid that serves to promote new muscle growth and is a precursor to the powerful ingredient dopamine. Dopamine is a highly sought after chemical that is organically secreted by the brain to enhance cognitive capabilities, increase mood, and kick your central nervous system into high gear. Proper L-Tyrosine supplementation stimulates the brain to release higher concentrations of dopamine so your body can power through a strenuous workout with much greater efficiency and cognitive function. L-Tyrosine has been shown to enhance concentration, increase attention span, improve mental performance under strenuous conditions, boost motivation, and improve multi-tasking ability. We have included a clinical dose of this powerful ingredient to ensure you are getting the best mind muscle connection during your workouts!

References:

Working Memory Reloaded: Tyrosine Repletes Updating in the N-Back Task

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863934/

Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance

https://pubmed.ncbi.nlm.nih.gov/25598314/

The effects of tyrosine on cognitive performance during extended wakefulness

https://pubmed.ncbi.nlm.nih.gov/7794222/

 Pink Himalayan Sea Salt

Pink Himalayan Salt has recently received a lot of support in the fitness community as it has proven to be beneficial for athletic performance. This variation of sodium is a natural alternative to table salt that is incredibly rich in minerals (research shows up to 84 trace minerals that are not contained in typical salt), minimizes muscle soreness, and helps maintain optimal hydration and electrolyte balance. Pink Himalayan Salt contains high amounts of potassium, calcium, magnesium, and iron. All of which play an important role in athletic performance and an overall healthy lifestyle. Hydration is key to performance and allows the body to function at its peak potential. Without the addition of high quality sodium, you will never be able hydrate optimally. This nutrient dense sodium also plays a huge role in muscle contraction. Therefore, it is a vital addition to any PreWorkout to push blood and nutrients to your muscle and provide you with a great "pump". Lets be real… we all love that swole, full as a house feeling when we are in the gym! We have included the ideal dose of Pink Himalayan Salt that has been shown through various reputable studies to provide the best results for our customers.

References:

BENEFITS OF PINK HIMALAYAN SALT FOR ATHLETIC PERFORMANCE

https://www.athsport.co/blogs/news/benefits-of-pink-himalayan-salt

Muscle Contraction: Regulation

https://onlinelibrary.wiley.com/doi/abs/10.1002/9780470015902.a0000674.pub2

Muscle cramps and magnesium deficiency: case reports

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2146789/

Fluid and electrolyte loss and replacement in exercise

https://pubmed.ncbi.nlm.nih.gov/1895359/

Water and electrolyte requirements for exercise

https://pubmed.ncbi.nlm.nih.gov/10410838/

Fluids and electrolytes

https://academic.oup.com/book/25122/chapter-abstract/189446843?redirectedFrom=fulltext

 Coconut Water Powder 

Our Coconut Water Powder is a high potency extraction from natural coconuts, one of natures hydration superfoods! This Coconut Water Powder contains more potassium and electrolytes than your leading sports drink to keep your muscles fed and your body in a properly hydrated state for peak performance during strenuous workouts. We chose to add a hefty dose of this premium, all-natural ingredient to minimize soreness, cramping, nausea, and fatigue so that nothing holds you back from the best possible athletic performance!

References:

Rehydration with sodium-enriched coconut water after exercise-induced dehydration

https://pubmed.ncbi.nlm.nih.gov/17883020/

Coconut water uses, composition and properties: a review

https://www.cambridge.org/core/journals/fruits/article/coconut-water-uses-composition-and-properties-a-review/411501C3BDBABC87F2C3200F65CC8F2C

Fluid and electrolyte loss and replacement in exercise

https://pubmed.ncbi.nlm.nih.gov/1895359/

Water and electrolyte requirements for exercise

https://pubmed.ncbi.nlm.nih.gov/10410838/

 PeakATP®

PEAK ATP® is a clinically validated and patented form of Adenosine 5’-Triphosphate (ATP) Disodium. It’s the only nutritional ingredient that is identical in structure to the ATP produced and used by the human body. All living cells use ATP for energy - it’s our body’s universal energy currency powering all biological reactions that allow cells to function and life to exist. ATP also fuels exercise. The demand for ATP is increased up to 1,000-fold during exercise, and ATP turnover can limit high-intensity performance. But not all ATP is used to power cellular processes. It’s also an important signaling molecule, particularly for nerves, muscles, and blood vessels. PEAK ATP® is a bioavailable form of functional energy that potentiates the role of ATP in the body, particularly in combination with exercise, allowing users to do more and achieve more, with less fatigue. PEAK ATP® increases ATP pools, providing greater ATP availability during times of increased energy demands (e.g. exercise), delaying fatigue, and enhancing performance.

Caffeine is the most prominent ingredient in the majority of products that are marketed for energy, including pre-workouts. While caffeine and other stimulants can promote focus, alertness, and enhance mood, these are only sensorial perceptions of ‘energy’ and don’t provide a sustainable source of energy to fuel performance. In contrast, PEAK ATP® provides real energy, identical to the form our bodies actually use to power movement. While other ingredients are precursors to the body’s production of ATP, PEAK ATP® actually delivers ATP directly to working muscles when the body needs it most. 

     What are the major Benefits of PEAK ATP®?

• Boosts Muscular Power Output
  
• Increases Total Strength by 147% Over Training Alone (Clinical Evidence)
  
• Increases Power by 30% Over Placebo (Clinical Evidence)
  
• Reduces Muscular Fatigue by promoting optimized recovery and improved vasodilation (Clinical Evidence)
  
• Increases Lean Body Mass by 100% Over Placebo (Clinical Evidence)
  
• Improves Blood Flow Up to 54% resulting in increased blood flow, oxygen delivery, and clearance of metabolic waste products such as lactate. (Clinical Evidence)
  
• Enlarges Muscle Calcium Pool which allows you to lift more weight and produce a greater number of repetitions per set.

     Who Benefits from PEAK ATP®?

Active Nutrition

These are everyday exercisers, whether  lifting weights, running, cycling, or hiking, who want (or need) a source of (real) functional energy to keep them going with less fatigue. Because PEAK ATP® supports increased work volume, it can help anyone make the most of time spent exercising.

Competitive Athletes

The benefits of PEAK ATP® are relevant to consumers who perform high intensity and/or exhaustive exercise that are looking to increase or enhance their work capacity – to “do more”. That is, the ability to perform more reps, more sets or push harder, for longer. This is the prime domain of sports nutrition, particularly the core consumer who is focused on resistance exercise and aesthetics with goals of increasing muscle size and strength or to be more “toned” or “shredded” (improved body composition). PEAK ATP® is also relevant in endurance exercise in order to delay the onset of fatigue.

Healthy Aging

In addition to exercise, ATP is critical for normal physiological function in all cells. However, it is particularly important in the functioning of the heart and blood vessels and in maintaining energy in the brain to support cognition and signals involved in sleep, memory, learning, and movement. ATP also helps maintain healthy function of the gut and related immune activity and supports building strong and healthy skeletal muscles to support bone structure. ATP metabolism and production decrease with age, particularly in the blood and skeletal muscle.

References:

Endo M. Calcium-induced calcium release in skeletal muscle. Physiol Rev. 2009, 89(4):1153-1176.

Wilson JM, et al. Effects of oral adenosine-5’-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men. Nutrition and Metabolism 10:57, 2013. A study performed by researchers at the University of Tampa.

Rathmacher JA, et al. Adenosine-5’-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high-intensity exercise sets. Journal of the International Society of Sports Nutrition 9:48, 2012. A study performed by researchers at Iowa State University.

Jäger, et al. Oral adenosine-5’-triphosphate (ATP) administration increases blood flow following exercise in animals and humans. Journal of the International Society of Sports Nutrition 11:28, 2014. A study performed by researchers at the University of Tampa.

Frietas et al. A single dose of oral ATP supplementation improves performance and physiological response during lower-body resistance exercise in recreational resistance-trained males. Journal of Strength and Conditioning Research, 33:3345-3352, 2019. A study performed by researchers at São Paulo State University.

Purpura M, et al. Oral Adenosine-50-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout. Journal of the American College of Nutrition, 2017. A study performed by researchers at the University of Tampa.

(The above information was taken directly from the PeakATP® product information page developed by TSI Group Co., Ltd / TSI USA LLC - https://www.peakatp.com/about)

 L-Norvaline  

L-Norvaline is an amino acid that stems from Valine, a popular Branch Chain Amino Acid (BCAA), and is found in many foods such as meats, dairy, nuts, and legumes. This amino acid is highly respected for its role in stimulating lean muscle development as it preserves optimal amounts of Arginine (described above) in the body. Our PreWorkout is carefully dosed in conjunction with Arginine to produce the most beneficial results from all the time you dedicate to training. L-Norvaline specifically acts to enhance Nitric Oxide production and regulate blood flow to the muscles to deliver the most favorable amount of nutrients needed for growth. This ingredient is shown to effectively lower blood pressure, reduce muscular inflammation, decrease soreness, and speed up recover times. We utilize a clinical dose of L-Norvaline in our PreWorkout to ensure that your body can perform to its greatest ability and ensure you properly recover as quickly as possible!

References:

The effect of nitric-oxide-related supplements on human performance

https://pubmed.ncbi.nlm.nih.gov/22260513/

Arginase inhibition alleviates hypertension in the metabolic syndrome

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682715/

Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664787/

Arginase modulates nitric oxide production in activated macrophages

https://pubmed.ncbi.nlm.nih.gov/9458885/

 Electrolyte Matrix (Pink Himalayan Sea Salt, Magnesium Citrate Anhydrous, Potassium Chloride) 

Electrolytes are an incredibly important, yet undervalued, component of any PreWorkout product. These naturally occurring nutrients support optimal fluid balance, cell function, and muscle hydration to enhance muscle contractions and lead to all around better performance. The additional supplementation of electrolytes has been shown to minimize cortisol levels, which are detrimental to lean muscle gains, and aid in faster recovery. The Electrolyte Matrix in 110% Nutrition PreWorkout is carefully dosed to keep your muscles fed and hydrated so that your body has the ability to perform at the highest levels under intense stress.

References:

Water and Electrolyte requirements for exercise

https://www.sciencedirect.com/science/article/abs/pii/S0278591905701654

Fluid and electrolyte needs for preparation and recovery from training and competition

https://www.tandfonline.com/doi/abs/10.1080/0264041031000140572

Water and electrolyte needs for football training and match-play

https://www.tandfonline.com/doi/abs/10.1080/02640410500482677

Fluid and electrolyte needs for training, competition, and recovery

https://www.tandfonline.com/doi/abs/10.1080/02640414.2011.614269

Effects of electrolyte and nutrient solutions on performance and metabolic balance.

https://europepmc.org/article/med/3343913

 BioPerine®

Black pepper extract (BioPerine®) is a standardized extract, prepared from the dried fruits of Piper nigrum (black pepper) and contains a minimum of 95% Piperine. It is clinically studied for its ability to enhance the bioavailability of the nutrients. In general, BioPerine® was found to enhance absorption of nutrients by at least 30%. It has been well recognized as a bioavailability enhancer for nearly two decades, and it is the only source of black pepper to have undergone clinical studies in the United States and several other countries, which substantiate its safety and efficacy for nutritional use.

Bioavailability is the key step in nutrient absorption, which ultimately decides the efficacy. To overcome the issue of bioavailability, several delivery methods have been employed to improve the absorption. Black pepper extract has been shown to enhance the bioavailability of fat-soluble vitamins (β-carotene), water-soluble vitamins (vitamin-C), selenoamino acid, coenzyme Q10, resveratrol and Curcumin (Fernández-Lázaro et al., 2020) . It was found that piperine was the key component behind the bioavailability enhancing the character of black pepper extract (Vladimir et al., 1999).

Thermogenesis is a metabolic process that generates energy at the cellular level in the human body and has been identified as a key factor in utilizing the dietary food and nutrients that the human body consumes. Piperine in the black pepper extract enhances the thermogenesis and in turn, affects the absorption of components in the intestine (Mhaske et al., 2018).

References:

A systematic review on black pepper (Piper nigrumL.): from folk uses to pharmacological applications https://pubmed.ncbi.nlm.nih.gov/30740986/

Iron and Physical Activity: Bioavailability Enhancers, Properties of Black Pepper (Bioperine®) and Potential Applications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353321/

Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation https://www.sciencedirect.com/science/article/abs/pii/S027153179900007X

Role of Piperine as an Effective Bioenhancer in Drug Absorption https://www.walshmedicalmedia.com/open-access/role-of-piperine-as-an-effective-bioenhancer-in-drug-absorption.pdf

(The above information was taken directly from the BioPerine® product information page developed by Sabinsa Corporation. - https://bioperine.com/aboutbioperine/black-pepper-extract/)

*These statements above have not been evaluated by the Food and Drug Administration.*